Southeastern Indiana Vacations from $420

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Your Southeastern Indiana Vacation

Head off on your next big adventure with a Southeastern Indiana vacation package, and leave knowing all the details are organized. And with the ability to customize your getaway, you know it'll be one to remember. Your trip to Southeastern Indiana wouldn't be complete without getting to some of its most well-known cities, starting with Louisville. A couple of the top attractions here include KFC Yum Center and Kentucky Kingdom. Radcliff should also be on the itineraries of all Southeastern Indiana travelers. Visitors to this exciting city love Freeman Lake Park and General George Patton Museum. Whether you're planning to travel for a few days or a few weeks, Expedia are here to help you tailor-make your next dream Southeastern Indiana vacation.

The Latest Southeastern Indiana vacation packages

Price found within the past 48 hours. Click for updated prices.
voco The Clair Cincinnati Downtown by IHG
Hyatt Regency Cincinnati
The Cincinnatian Hotel Curio Collection by Hilton
21c Museum Hotel Cincinnati
Hotel Covington Cincinnati Riverfront
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Black Friday Sale

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Where to stay in Southeastern Indiana

Find the best Southeastern Indiana areas and neighborhoods for the activities you enjoy most. Learn more about Southeastern Indiana

Discover the most popular places to visit in Southeastern Indiana

Southeastern Indiana Hotel Deals

Radisson Hotel Louisville North

Radisson Hotel Louisville North

3 out of 5
505 Marriott Drive Clarksville IN
Fully refundableReserve now, pay when you stay
$48 nightly
The price is $54 total per night from Dec 3 to Dec 4
$54 total
Dec 3 - Dec 4
Total with taxes and fees
6.8/10 (2,547 reviews)
Affordable and luxurious

Reviewed on Nov 24, 2025

Radisson Hotel Louisville North
Hilton Garden Inn Jeffersonville Louisville North

Hilton Garden Inn Jeffersonville Louisville North

3 out of 5
4900 Water Tower Road Jeffersonville IN
Fully refundableReserve now, pay when you stay
$83 nightly
The price is $94 total per night from Dec 5 to Dec 6
$94 total
Dec 5 - Dec 6
Total with taxes and fees
9.4/10 Exceptional! (388 reviews)
Very modern and clean, friendly front desk personnel, and courteous restaurant staff

Reviewed on Nov 23, 2025

Hilton Garden Inn Jeffersonville Louisville North
Comfort Inn & Suites Clarksville - Louisville North

Comfort Inn & Suites Clarksville - Louisville North

2.5 out of 5
1485 Broadway St Clarksville IN
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $106 total per night from Dec 7 to Dec 8
$106 total
Dec 7 - Dec 8
Total with taxes and fees
8.8/10 Excellent! (1,011 reviews)
Clean rooms and great staff

Reviewed on Nov 23, 2025

Comfort Inn & Suites Clarksville - Louisville North
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Southeastern Indiana Vacation Packages

Southeastern Indiana Essential Information

Language
English
Currency
U.S dollars
Closest Airport
O'Hare Intl. Airport (ORD)

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.